Mix the cream cheese with the Italian seasoning and garlic powder until blended.
Spread about 1 heaping Tablespoons of the cream cheese mixture over 1 tortilla.
Place 2 slices of roast beef on the tortilla.
Roll tightly and repeat.
Place the tortilla rolls on a plate with seams down and refrigerate for at least 30 minutes before slicing.
Cut into 1/2 inch slices before serving.